Optimization of the Formulation of Paeonol-SPE_7-?-CD Inclusion Complex Tablets / 中国药房

OBJECTIVE:To optimize the formulation of paeonol-SPE7-?-CD inclusion complex tablets.METHODS:The formulation was optimized by orthogonal test with dissolution rate serves as index and the amount of adhesive(10% starch paste),disintegrant(dry starch)and lubricant(magnesium stearate)served as major factors,meanwhile a verification test was conducted.RESULTS:The optimum formulation of paeonol-SPE7-?-CD inclusion complex tablets was as follows:paeonol-SPE7-?-CD 106.2 g,lactose 48.7 g,10% starch paste 3.0 g,dry starch 6.0 g,and magnesium stearate 0.1g.The mean dissolution rate was 95.56% for three batches of samples prepared under the above condition.CONCLUSION:The optimized formulation is ideal and feasible.